Why does the generic drug not work as fast as the real one?
Generic medicine contains the same amount of the same active substance as the original medicine. It, therefore, has the same efficacy and the same safety in use as the original drug. The studies of bioequivalence thus make it possible to ensure that the generic drug acts in the same way in the body and, therefore, to verify that the manufacturing processes and excipients do not question the molecule's efficacy and safety. If you have any doubts about your treatment, talk to your doctor, who will be able to advise and reassure you. In any case, do not change the dosage of your medicine without consulting your doctor first. Note that the differences observed during the administration of a generic drug are the same as those observed during the administration of a brand-name drug: this is due to individual susceptibility.
Why is the generic drug amlodipine not suitable for me?
The generic drug treats the same way as the brand-name drug. Scientific studies confirm this, both in terms of efficacy and safety. An analysis of the scientific literature confirms the equivalence of generic cardiovascular drugs with originator drugs in terms of clinical results. You will find more information on this study by consulting the Effective and Safe Medicines page on the bmpharmacy generic pharmacy website. Do not hesitate to talk about it with your doctor, who will be able to reassure you and advise you.
Why is a specific drug less effective than the original drug while generic other medicines work?
The generic drug treats the same way as the brand-name drug. Scientific studies confirm this, both in terms of efficacy and safety. The differences observed during the administration of a generic drug are the same as those observed during a brand-name drug. These differences are due to individual susceptibility and do not call into question the efficacy and safety of the drug, whether generic or not. However, if you have a problem with a medication, do not hesitate to discuss it with your pharmacist, who can advise you on another.
How come I can't stand generic drugs, and they are less effective than brand-name drugs?
The generic drug treats the same way as the brand-name drug. Scientific studies confirm this, both in terms of efficacy and safety. The differences observed during the administration of a generic drug are the same as those observed during a brand-name drug. These differences are due to individual susceptibility and do not call into question the efficacy and safety of the drug, whether generic or not. However, if you have any doubts, talk to your doctor to give you the best advice.
Why did my TSH change when I switched to the generic levothyroxine medication?
The example of levothyroxine that you cite is one of the so-called "narrow therapeutic margin" drugs for which the confidence interval which makes it possible to judge the bioequivalence is tightened. These drugs are characterized by toxic or ineffective concentrations close to effective concentrations. Therefore, slight variations in dose or concentration may lead to a change in the benefit/risk ratio. In this logic, any change during treatment must be carried out with care, whether it involves switching from one originator to another, from one originator to a generic specialty, or from one generic thing to another. The dosage adjustment is sensitive for both the generic drug and the original drug. It should be noted that no proof has been provided to date that there is a risk in substituting drugs with a narrow therapeutic margin.
Are generic drugs still as effective as brand-name drugs?
The generic drug treats the same way as the brand-name drug. Indeed, to obtain the status of a "generic" drug, a drug must contain the same active ingredient in the same quantity and prove its bioequivalence with the original medicine, that is to say, to prove that it has the same effectiveness and the same safety of use. Numerous scientific studies have compared the efficacy and the safety of the use of generic drugs and original drugs, confirm this.
Does a generic drug produce the same effect as a non-generic?
Yes, absolutely. To obtain "generic" drug status, a drug must prove its bioequivalence with the original medicine, i.e., verify that it behaves in the same way in the body. Therefore, the generic drug must demonstrate that the number of active ingredients available in the blood and the speed at which this active ingredient reaches the bloodstream are similar to those of the original drug. This bioequivalence is the guarantee of therapeutic efficacy and safety of use identical to those of the original drug. This proof must be provided in the file compiled by the laboratory to obtain a marketing authorization (AMM) issued by the National Agency for the Safety of Medicines and Health Products (ANSM), authorization required for marketing. Of the drug.