Latisee Bimatoprost 0.03mg





Latisse After application of the drug in the form of drops at a concentration of 0.03%, maximum plasma levels are observed after 10 minutes, and after 1.5 hours they decrease to a minimum (0.025 ng / ml). The mean peak plasma levels and AUC values ​​on days 7 and 14 were approximately the same (0.08 and 0.09 ng x h / ml, respectively). There was no significant systemic accumulation of the substance. The active ingredient is distributed inside the tissues and the level of equilibrium in the volume of distribution is 0.67 l / kg. Inside the plasma, bimatoprost is mainly found in a protein synthesized form. Only 12% of the substance remains free inside the circulatory system. Most bimatoprost enters the bloodstream unchanged. In addition, the processes of ethylation, oxidation as well as glucuronization, resulting in various degradation products.