After application of the drug in the form of drops at a concentration of 0.03%, maximum plasma levels are observed after 10 minutes, and after 1.5 hours they decrease to a minimum (0.025 ng / ml). The mean peak plasma levels and AUC values on days 7 and 14 were approximately the same (0.08 and 0.09 ng x h / ml, respectively). There was no significant systemic accumulation of the substance. The active ingredient is distributed inside the tissues and the level of equilibrium in the volume of distribution is 0.67 l / kg. Inside the plasma, bimatoprost is mainly found in a protein synthesized form. Only 12% of the substance remains free inside the circulatory system. Most bimatoprost enters the bloodstream unchanged. In addition, the processes of ethylation, oxidation as well as glucuronization, resulting in various degradation products.
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Use Latisse during pregnancy
Oral administration of bimatoprost in excess of the recommended topical application 33-97 times was tested during animal testing. In such experiments, miscarriages occurred in animals. After using the substance at a dose exceeding 41 times the drug, there was a decrease in the gestation period, an increase in the number of fetal deaths, as well as a decrease in the weight of newborns. Controlled Latisse drops in pregnancy were not tested. Animal tests have also confirmed that bimatoprost may pass into breast milk. Therefore, breastfeeding should be discontinued when taking medication.
Contraindications
Main contraindications: children under 18 years of age, and with them the presence of intolerance to medicinal ingredients. Use caution when using people with powerlessness or pseudoafakia, as well as with damage to the posterior lens capsule. In addition, they must be used with caution during long-term diabetes high risk of macular edema, increased blood pressure (especially if there are high diastolic pressure), high cholesterol, nephropathy, as uveitis (due to this disease may develop in this case) .
Dosage and administration Drops are used once a day - before bedtime. Beforehand, you need to remove decorative cosmetics from the face and remove contact lenses (if available). It is required to drip 1 drop of drugs on a special applicator, and then evenly process the skin along the border of cilia growth in the upper eyelid - it is required to run the applicator along its edge. To moisten the upper eyelid in the place of eyelash growth should be only slightly, and the drug can not flow beyond the boundaries of this line. To avoid excessive moisture, remove excess medicine. The used applicator is thrown away immediately and then banned. To process the second eyelid, you need to take a new applicator. When using Latisse, it is prohibited to use other applicators (not those contained in the medicine pack) or a brush. You can't treat the lower eyelids. In addition, make sure that the droplet of the bottle with the droplets does not come into contact with any surfaces - so that there is no infection.. Buy Latisse Canada
Latisse side effects
Get emergency medical help if you have signs of an allergic reaction to Latisse: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: severe burning or itching of your eyes; eye swelling, vision problems, eye pain, seeing halos around lights; redness, severe discomfort, crusting or drainage (may be signs of infection); increased sensitivity to light; or feeling like something is in your eye.